Periventricular zone involvement as a predictor of survival in glioblastoma patients: A single centre cohort-comparison investigation concerning a distinct clinical entity

• Subventricular Zone (SVZ) contains neural progenitor cells. SVZ Gliomas may demonstrate a more aggressive behavior. were associated with shorter Overall Survival. Progression Free not different immuno-histochemical pattern for p53, EGFR, ki67 e IDH1. Glioblastoma (GBM) contacting the display of invasiveness higher potential to recruit migratory We aims determine relationships between location lesion and clinical, molecular characteristics outcome in patients affected by GBM. The surgical, radiological clinical outcomes have been retrospectively reviewed present study. All classified according their anatomical relationship + SVZ-. A review our surgical series was conducted compare results tumors regards characteristics, localization, Extent Resection (EOR). Uni- Multivariate ANOVA survival analyses performed investigate cohort. total 177 included final s tatistical analysis means multivariate that significantly greater volume at presentation, lesser EOR, functional postoperative short overall survival. There are specific consider GBMs entity how Headache Sensory Disturbances, which risk partial resection less satisfactory early period. Our demonstrated clear statistically significant advantage cortical GBM over V-SVZ